Question Details

[answered] A. From the data given for the rs62224609 locus, what is th


A.? From the data given for the rs62224609 locus, what is the estimated value of Hs and Ht, and Fst for humans?? Now calculate the same using all loci and give the average values for each.? What is the best estimate of total inbreeding in the world, how do you interpret this number?

B.? Just considering GBR, FIN, and CHS, and for the rs62224609 locus, calculate Hi, Hs, Ht, Fit, Fis, and Fst,.? Now calculate same when based on all loci for those populations.

C. Based only on B, Is there subpopulation structure within GBR, FIN or CHS?? Explain

D.? Compare the Fst obtained in B with that in A.? Would you expect the value in B to be greater than, the same, or less than A?? Why?

There?d be a difference because we are only examining the subpopulation in part B.

E.? The coefficient of relationship between any two individuals in a pedigree can be found as the probability of IBD (see slide 46 of 4th set).? Without pedigrees the same value can be calculated based on the assumption that a given SNP occurred only once and is IBD with any individual who shares it.? Based on the definition of coefficient of relationship, calculate the relationship between 2 individuals in GBR (HG00096 with HG00097) and 2 individuals in CHS (HG00403 with HG00404).and the relationship between individuals of the countries GBR and CHS (HG00096 with HG00403). (hint, remember that IBD is based on 4 probabilities, the draw of the 2 alleles at that locus in the first individual and the draw of the 2 alleles at the locus in the 2nd individual. if both individuals have the same homozygous genotype, they share 2 alleles IBD and the average of the 4 probabilities is 1; if both are opposite homozygotes, they share 0 and the probability is 0; a het with a homo, they shares 1 with probability 1/2, a het with a het shares 1 with probability 1/2, see slide 48 from the 4th set of notes).

F.? From the 2nd definition of inbreeding, which is the probability that two alleles within an individual at the same locus are IBD (see Slide 29, 3rd set of notes), how much inbreeding would result if HG00096 with HG00097 mated with each other; or HG00403 with HG00404; or HG00096 with HG00403 (assuming they are opposite sex, naturallyJ.? .From this example, what general conclusion can you make about inbreeding and relationships?? If you can't figure out how to get Excel to do this across loci, just use the rs62224609 locus for partial credit

G.? Can you detect any signatures of selection between any of the super-populations?? Show calculations.

 


Solution details:
STATUS
Answered
QUALITY
Approved
ANSWER RATING

This question was answered on: Sep 18, 2020

PRICE: $15

Solution~0001003822.zip (25.37 KB)

Buy this answer for only: $15

This attachment is locked

We have a ready expert answer for this paper which you can use for in-depth understanding, research editing or paraphrasing. You can buy it or order for a fresh, original and plagiarism-free copy from our tutoring website www.aceyourhomework.com (Deadline assured. Flexible pricing. TurnItIn Report provided)

Pay using PayPal (No PayPal account Required) or your credit card . All your purchases are securely protected by .
SiteLock

About this Question

STATUS

Answered

QUALITY

Approved

DATE ANSWERED

Sep 18, 2020

EXPERT

Tutor

ANSWER RATING

GET INSTANT HELP/h4>

We have top-notch tutors who can do your essay/homework for you at a reasonable cost and then you can simply use that essay as a template to build your own arguments.

You can also use these solutions:

  • As a reference for in-depth understanding of the subject.
  • As a source of ideas / reasoning for your own research (if properly referenced)
  • For editing and paraphrasing (check your institution's definition of plagiarism and recommended paraphrase).
This we believe is a better way of understanding a problem and makes use of the efficiency of time of the student.

NEW ASSIGNMENT HELP?

Order New Solution. Quick Turnaround

Click on the button below in order to Order for a New, Original and High-Quality Essay Solutions. New orders are original solutions and precise to your writing instruction requirements. Place a New Order using the button below.

WE GUARANTEE, THAT YOUR PAPER WILL BE WRITTEN FROM SCRATCH AND WITHIN YOUR SET DEADLINE.

Order Now