Lecture 15 Axon 81 Dendrite Development -Axons and dendrites are distinct morphologically & biochemically -Cell morphogenesis proceeds in distinct (but temporally overlapping ) stages -Cytoskeletal reorganization is key at every stage -Microtubules & actin filaments act in concert to direct cell morphogenesis -The growth cone is a specialized structure that mediates neurite formation and axon guidance -Microtubule advance and bundling is essential in neurite outgrowth & guidance -Actin ?laments are essential and their polymerization drives growth cone extension -F-actin filopodia & arcs regulate microtubule movements in growth cones -Neuronal polarity (i.e., axon specification) involves similar mechanisms as in other cells: Par complex, motors, cytoskeletal mechanisms involving small G-proteins of the Rho family
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