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[answered] Lecture 16 Axonal Transport 81 Local Membrane Trafficking N


Lecture 16 Axonal Transport 81 Local Membrane Trafficking Neurons have a special requirement for long-distance transport of material, but also a need to regulate material delivery at individual synapses Microtubule?based movement: Long-distance transport is mediated by molecular motors (kinesin and dynein) that use microtubules as tracks Cargoes include membranous organelles, cytoskeleton, mRNAs, viruses Different types of cargos move at different speeds along the axon (?fast? versus ?slow? axonal transport) Dynein moves cargo retrogradely; kinesins (mostly) move cargo anterogradely Motors utilize ATP hydrolysis to perform work; ATP binding & hydrolysis induce conformational changes that power the movement
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